Accession Number : AD1007943


Title :   7T Magnetization Transfer and Chemical Exchange Saturation Transfer MRI of Cortical Gray Matter: Can We Detect Neurochemical and Macromolecular Abnormalities


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Vanderbilt University Nashville United States


Personal Author(s) : Smith,Seth A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1007943.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 37


Abstract : We present the second annual report for this project. We have developed and deployed a quantitative MRI set of MRI scans at 7T in healthy volunteers and patients with MS, developed an analysis pipeline and QA for the quantification of macromolecular and metabolic indices reflective of demyelination and neurotransmitter/protein accumulation. All quantitative acquisitions have been evaluated for reproducibility. Behavioral testing shows significant differences between MS and healthy volunteers, along with fMRI, and CEST acquisitions. Analysis hurdles were noted in the qMT, which we discuss here. Recruitment continues in the MS cohort (all healthy subjects have been recruited) during the EWOF. Correlation analysis have been examined, and a translation to lower field strength has generated many further outcomes.


Descriptors :   magnetic resonance imaging , brain , cognitive impairment , Magnetization , GLUTAMATES , central nervous system


Distribution Statement : APPROVED FOR PUBLIC RELEASE