Accession Number : AD1007777


Title :   Pulmonary Stress Induced by Hyperthermia: Role of Airway Sensory Nerves


Descriptive Note : Technical Report,30 Sep 2010,28 Oct 2015


Corporate Author : University of Kentucky Research Foundation Lexington United States


Personal Author(s) : Lee,Lu-Yuan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1007777.pdf


Report Date : 01 Jan 2016


Pagination or Media Count : 128


Abstract : Based upon the results obtained from these studies, we can draw the following conclusions: 1) Airway hyper responsiveness developed in Ova-sensitized mice was less pronounced in TRPV1-null mice, indicating an important role of TRPV1. 2) An increase in airway temperature within the normal physiological range triggered bronchoconstriction in sensitized rats, but not in control rats. Chronic airway inflammation in sensitized animals is likely a major contributing factor in causing this response. 3) A transient increase in airway resistance was generated immediately after hyperventilation with warm humid air in patients with mild asthma, but the same warm humid air challenge failed to cause any bronchoconstriction in healthy subjects. Furthermore, this bronchoconstriction is likely generated by the increase in airway temperature because hyperventilation with humidified air at room temperature did not generate any change in airway resistance in the same patients. These studies, once completed, should provide important and novel information for: 1) documenting the pulmonary stresses induced by hyperthermia in healthy individuals and in patients with sensitized airways; 2) understanding the mechanism underlying the hyperthermia-induced pulmonary dysfunction; and 3) detecting the susceptibility to heat stress in soldiers with underestimated or overlooked airway hypersensitivity such as in airway allergy or mild asthma.


Descriptors :   peripheral nervous system , asthma , hyperthermia , constrictions , respiratory physiological phenomena , rodents , inflammation


Distribution Statement : APPROVED FOR PUBLIC RELEASE