Accession Number : AD1007602


Title :   The Role of Retinal Determination Gene Network (RDGN) in Hormone Signaling Transduction and Prostate Tumorigenes


Descriptive Note : Technical Report,30 Sep 2011,29 Sep 2015


Corporate Author : Thomas Jefferson University Philadelphia United States


Personal Author(s) : Ju,Xiaoming ; Wu,Kongming


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1007602.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 13


Abstract : These studies were conducted to determine the function of DACH1 in regulating prostate cancer growth in vitro and in vivo, and to determine the normal function of DACH1 in prostate development. We demonstrated that DACH1 suppresses prostate cancer cellular growth induced by ErbB2. We demonstrated similar mechanisms govern DACH1 restrain of prostate tumorigenesis promoted by Ras, c-Myc and c-Src. We identified the key molecular targets regulated by DACH1 in vitro and in vivo and showed using ChIP analysis the binding of DACH1 tokey target genes. We used genetic deletion studies to identify the key function for DACH1 in restraining cytokine secretion. IL-8 and IL-6 are the key cytokines demonstrated to promote prostate cancer growth andwe showed that DACH1 is the key endogenous mechanism governing restraint of prostate epithelial cell cytokinesecretion (IL-8 and IL-6).


Descriptors :   prostate cancer , genes , androgen , cytokines


Distribution Statement : APPROVED FOR PUBLIC RELEASE