Accession Number : AD1007576

Title :   Treatment of Early Post-op Wound Infection after Internal Fixation

Descriptive Note : Technical Report,15 Sep 2014,14 Sep 2015

Corporate Author : Vanderbilt University Medical Center Nashville United States

Personal Author(s) : Obremskey,William

Full Text :

Report Date : 01 Oct 2015

Pagination or Media Count : 5

Abstract : Severe fractures are common in modern warfare with fractures being fixed via internal fixation of plates and screws to hold the fracture stable while the bone heals. Approximately 10%-40% of severe fractures fixed with internal fixation develop a deep wound infection during the healing process. Thus, the overall goals of this study are to (1) evaluate the effect of treatment of post-op wound infection in long bones after fracture fixation or joint fusion and either: (Group 1) operative debridement and PO antibiotic treatment for 6 weeks; or (Group 2) operative debridement and IV antibiotics for 6 weeks and (2) build and validate a risk prediction model for failure of treatment of early postoperative wound infections after fixation of fractures or joint fusion.

Descriptors :   infection , therapeutics , Antibiotics , DEBRIDEMENT , drug therapy , Oral dosage , bone fractures , Wounds and injuries

Distribution Statement : APPROVED FOR PUBLIC RELEASE