Accession Number : AD1007485


Title :   Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR)


Descriptive Note : Technical Report,30 Sep 2012,29 Sep 2015


Corporate Author : University of Colorado, Boulder Boulder United States


Personal Author(s) : Watkins,Linda R ; Maier,Steven ; Bachtell,Ryan ; Katz,Jonathan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1007485.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 28


Abstract : This 3 year multi-site project is now complete. It has successfully studied the role of toll like receptor 4 in both opioid and cocaine reward / reinforcement. In addition it has successfully documented the potential of ( )naltrexone (a clinically relevant, blood brain barrier permeable, non-opioid toll like receptor 4antagonist) as an inhibitor of the rewarding / reinforcing effects of cocaine and opioids. Notably, it suppresses reinstatement to drug seeking (relapse)supportive of the interest in this compound for aiding drug abusers in the goal of avoiding relapse. In exploring brain mechanisms underlying these effects, we have accrued evidence supportive of both nucleus accumbens and ventral tegmental nucleus involvement.


Descriptors :   Drug abuse , therapeutics , GLIAL CELLS , Drug addiction , morphine , Cocaine , Dopamine


Distribution Statement : APPROVED FOR PUBLIC RELEASE