Accession Number : AD1006818


Title :   Contribution of Interstitial Deletion of 21q22.2-3 per se to Prostate Cancer Progression in Tumors Harboring TMPRSS2-ERG Translocations


Descriptive Note : Technical Report,15 Sep 2014,14 Sep 2015


Corporate Author : Tulane University New Orleans United States


Personal Author(s) : Dong,Yan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1006818.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 11


Abstract : TMPRSS2-ERG gene fusions are present in close to 50% of human prostate cancers. Approximately half of the fusions are generated through an interstitial deletion between these two genes, and the other half through an interchromosomal insertion. The deletion class is in general more aggressive than the insertion class. The purpose of this study is to understand the mechanism underlying the aggressive phenotype of the deletion class of TMPRSS2-ERG-positive prostate cancers. We identified two potential tumor suppressor genes in this deleted region. The loss of these two genes may work together withTMPRSS2-ERG to drive prostate cancer progression. Understanding the function of the interstitial deletion may provide markers to distinguish aggressive from indolent disease and will facilitate rational design of therapeutic approaches to improve the treatment of this appreciable group of patients.


Descriptors :   prostate cancer , ANTINEOPLASTIC AGENTS , gene expression , neoplasms


Distribution Statement : APPROVED FOR PUBLIC RELEASE