Accession Number : AD1006434

Title :   Dissecting the Roles of Brain Injury and Combat-Related Stress in Post-Traumatic Headache

Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author : University of Utah Salt Lake City United States

Personal Author(s) : Brennan,K C ; Kaufmann,Dan ; Sawant,Punam ; Theriot,Jeremy

Full Text :

Report Date : 01 Oct 2015

Pagination or Media Count : 16

Abstract : Military traumatic brain injury (TBI) typically involves blast exposure, and typically occurs in an environment of extreme stress. One of the most common and debilitating consequences of TBI is post-traumatic headache (PTH). Because both TBI and stress could contribute to PTH, we examine them together and separately, attempting to understand the mechanisms by which they generate PTH, and to develop new treatments for the disorder tailored to both injury and stress mechanisms.In the first year of this project, a significant portion our time has been spent in the ACURO approval process. We obtained ACURO approval in the middle of the third quarter of the calendar year. Prior to ACURO approval (on an unfunded basis) weset up the blast apparatus in our lab and began validation work in this new setting. Since ACURO approval, we have continued validation work for all of the modalities we will need in the project (blast, sensory physiology, and behavior) and begun experiments.

Descriptors :   traumatic brain injuries , headaches , STRESS PSYCHOLOGY , blast , EXPOSURE PHYSIOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE