Accession Number : AD1006395


Title :   Imaging Prostate Cancer Microenvironment by Collagen Hybridization


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : University of Utah Salt Lake City United States


Personal Author(s) : Yu,Michael S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1006395.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 14


Abstract : The major goal of the proposed work is to develop new PCa imaging methods based on the collagen mimetic peptide (CMP)- mediated structural interrogation of the collagens associated with invasive tumor. In this proposal, we propose to use collagen mimetic peptide (CMP) as a collagen targeting agents that will allow imaging of invasive PCa. Since CMP binds to unstructured collagens more readily, it is expected to exhibit selective affinity to metastatic PCa tumors known to contain processed and denatured collagens. The motivating hypothesis is that the CMPs ability to bind to collagen/denatured collagen can be used to image PCa in vivo as well as to determine the level of PCa malignancy.


Descriptors :   prostate cancer , cancer research , DIAGNOSTIC IMAGING , neoplasms , targets , metastasis , therapeutics , pharmacokinetics , cellular microenvironment


Distribution Statement : APPROVED FOR PUBLIC RELEASE