Accession Number : AD1006379


Title :   Optimization of Soft Tissue Management, Spacer Design, and Grafting Strategies for Large Segmental Bone Defects using the Chronic Caprine Tibial Defect Model


Descriptive Note : Technical Report,30 Sep 2013,29 Sep 2015


Corporate Author : Henry M Jackson Foundation for the Advancement of Military Medicine Bethesda United States


Personal Author(s) : Forsberg,Jonathan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1006379.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 18


Abstract : This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The results showed that scraping the inner surface of the induced membrane provided a highly desirable environment that promoted more bone regeneration by providing exposure of the autograft placed in the defect site to fresh blood and competing non-osteogenic cells.


Descriptors :   military medicine , bone fractures , tibia , surgical transplantation , connective tissue


Distribution Statement : APPROVED FOR PUBLIC RELEASE