Accession Number : AD1005936


Title :   Optimal Treatment of Malignant Long Bone Fracture: Influence of Method of Repair and External Beam Irradiation on the Pathway and Efficacy of Fracture Healing


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Medical University of South Carolina Charleston United States


Personal Author(s) : Pellegrini,Vincent D ; Lin,Zilan X


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1005936.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 20


Abstract : The purpose of this project is to characterize the differential effects of radiation on the two pathways of fracture healing in an established animal model of bilateral femur fracture repair. Micro CT data obtained from 18 animals in the year 1 SOW (Group I) have been analyzed to assess callus volume and character. Data on RNA isolation and PCR array on 18 animals in the year 1 SOW (Group II) are being analyzed at the partner lab at University of Maryland. Surgical procedures consisting of bilateral femur fracture and repair have been completed on both planned study cohorts (Groups III and IV; total of 40 animals) in the year 2 SOW; all animals were imaged and have been sacrificed according to protocol schedule. Both 6 month (Group III) and 3 month (Group IV) specimens underwent biomechanical testing, and data have been analyzed. Surgical procedures on the bilateral plate group of 9 animals recently added by amendment are being performed. Year 3 SOW animal procedures in Group V for histological testing will begin on schedule in the ninth quarter of the award.


Descriptors :   bone fractures , radiation , surgical procedures , healing , irradiation , bone cancer , metastasis


Distribution Statement : APPROVED FOR PUBLIC RELEASE