Accession Number : AD1005291


Title :   Functional Analysis of Frequent Lung Cancer Amplicons Under Current Genome Annotation


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Eastern Virginia Medical School Norfolk


Personal Author(s) : Mu,David


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1005291.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 9


Abstract : A significant number of lung cancer amplicons were established between mid and late 2000s using the array-based genomic tools. Thus, the known gene compositions of many MRAs are devoid of the genes only recently discovered. Exemplary groups of such genes include many non-protein-coding genes like long non-coding RNAs and microRNAs (miRNAs). In study, we examined the PVT1-encoded miRNAs embedded in one of the most recurrent amplicons at 8q24. The results indicate that these miRNAs are not likely functionally relevant to lung tumorigenesis. The implication is that future studies of the 8q24 amplicon should concentrate on characterizing the PVT1 RNA transcript.


Descriptors :   lung cancer , Ribonucleic acids , genomics , GENOME COMPONENTS , Oncogenesis


Distribution Statement : APPROVED FOR PUBLIC RELEASE