Accession Number : AD1005118

Title :   Tinnitus Multimodal Imaging

Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author : University of California, San Francisco San Francisco United States

Personal Author(s) : Cheung,Steven W ; Nagarajan,Srikantan S

Full Text :

Report Date : 01 Oct 2015

Pagination or Media Count : 25

Abstract : Tinnitus is a common auditory perceptual disorder whose neural substrates are under intense debate. This project takes a multimodal imaging approach to better understand whole brain network connectivity abnormalities. Resting-state fMRI reveals increased corticostriatal connectivity isolated to area LC of the caudate, which is positioned at the junction of the head and body of the nucleus. Other patterns of increased connectivity include caudate head with cingulate gyrus of the default mode network. Those findings provide further evidence to support the striatal gating model of tinnitus, where dysfunctionally permissive area LC enables auditory phantoms to reach perceptual awareness. Magnetoencephalographic resting-state functional connectivity imaging (MEGI) in tinnitus subjects in the alpha-band shows increased connectivity in bilateral middle frontal gyrus (MFG), left postcentral gyrus, and left inferior parietal lobule. 7T MR spectroscopic imaging (MRSI) methods have successful capture of distinct GABA signals in the caudate nucleus and auditory cortices reliably.


Distribution Statement : APPROVED FOR PUBLIC RELEASE