Accession Number : AD1004091


Title :   A Novel Tumor Antigen and Foxp3 Dual Targeting Tumor Cell Vaccine Enhances the Immunotherapy in a Murine Model of Renal Cell Carcinoma


Descriptive Note : Technical Report,15 Sep 2013,14 Sep 2015


Corporate Author : Health Research, Inc Buffalo United States


Personal Author(s) : Shen,Li


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1004091.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 56


Abstract : A major barrier in vaccine therapy is represented by the presence of immunosuppressive factors predominant in cancer patients, such as regulatory T cells (Tregs) and suppressive myeloid cells, including myeloid derived suppressor cells(MDSCs) and tumor associated macrophages (TAMs). Here we report a tumor cell vaccine designed to target both tumor cells and Tregs by using Foxp3, a Treg-functional protein as an antigen in tumor cell vaccine. During first year of the project, we have demonstrated that the dual target vaccine had anti-tumor activity against established tumor. During last year, we tested a combination strategy to target suppressive myeloid cells (MDSCs and TAMs) with a pharmacological approach, tasquinimod, combined with dual targeting vaccine. The combination strategy prolonged survival, compared to vaccine single treatment. Overall, our results suggest that targeting immunosuppressive cells with vaccine or pharmacological strategies, results in greater anti-tumor activity and therapeutic efficacy, and provides foundation to test the strategy in clinical setting for patients with advanced, metastatic kidney cancer.


Descriptors :   cancer , carcinomas , neoplasms , KIDNEY DISEASES , neoplasms , T LYMPHOCYTES , MACROPHAGES , VACCINES , IMMUNOSUPPRESSION


Distribution Statement : APPROVED FOR PUBLIC RELEASE