Accession Number : AD1004075


Title :   Biomarkers for Autism and for Gastrointestinal and Sleep Problems in Autism


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Yale University New Haven United States


Personal Author(s) : Anderson,George M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1004075.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 13


Abstract : The nighttime and daytime excretions of melatonin sulfate were not significantly different between typically developing (TD) toddlers and toddlers with autism spectrum disorders(ASDs). Sleep and gastrointestinal(GI)problems were not associated with lower melatonin excretion in TD or ASD toddlers and to a large extent these problems occurred at similar rates in the TD and ASD groups. The expected day-night differences in melatonin sulfate excretion, and in norepinephrine and epinephrine excretion, were seen in both groups. Thus, the lower melatonin production reported for older children with ASD does not appear to occur in toddlers with ASD.


Descriptors :   MELATONIN , GASTROINTESTINAL SYSTEM , sleep , children , NEUROPHYSIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE