Accession Number : AD1003999


Title :   Making Aggressive Prostate Cancer Quiescent by Abrogating Cholesterol Esterification


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Purdue University West Lafayette United States


Personal Author(s) : Cheng,Ji-Xin


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1003999.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 12


Abstract : Our overall objective in the current application is to establish the viability of a new strategy of treating late stage PCa through therapeutic targeting of cholesterol metabolism in vivo, using combination of cutting edge spectroscopic imaging and other technologies, including biochemistry assays and preclinical testing. The innovation of this study is that it targets altered cholesterol metabolism, an understudied field of cancer research. Our central hypothesis is that abrogating cholesterol esterification events will result in an effective strategy for treating late stage PCa. This hypothesis will be tested by first validating the presence of altered cholesterol metabolism in human prostate cancer patient specimens. We will then evaluate the therapeutic benefit of CE depletion in appropriate animal models of PCa, and elucidate pathways linking cholesterol metabolism with cancer aggressiveness. An interdisciplinary research team has been assembled, with expertise in spectroscopic imaging and nanomedicine (Dr. J. X. Cheng, PI), biochemistry (Dr. X. Liu, co-PI), and prostate cancer biology (Dr. T. Ratliff, co-PI).


Descriptors :   prostate cancer , DORMANCY , CHOLESTEROL , METABOLISM , CHOLESTERYL ESTERS , Raman spectroscopy


Distribution Statement : APPROVED FOR PUBLIC RELEASE