Accession Number : AD1003301

Title :   Identifying microRNAs that Regulate Neuroblastoma Cell Differentiation

Descriptive Note : Technical Report,01 Sep 2014,31 Aug 2015

Corporate Author : University of Texas Health Science Center San Antonio United States

Personal Author(s) : Du,Liqin ; Zhao,Zhenze ; Pertsemlidis,Alexander ; Ma,Xiuye

Full Text :

Report Date : 01 Oct 2015

Pagination or Media Count : 27

Abstract : In this reporting period, we mainly focused on characterizing another novel differentiation-inducing miRNA, miR-449a. We examined the differentiation-inducing function of miR-449a in multiple neuroblastoma cell lines. We have demonstrated that miR-449a functions as an inducer of cell differentiation in neuroblastoma cell lines with distinct genetic backgrounds, including the MYCN amplification status. We further show that miR-449s mimic induces cell cycle exit, induces cell apoptosis, and decreases the capacity of the neuroblastoma cells to form colonies. Our results support the strong tumor suppressive function of miR-449a in neuroblastoma cells, providing the experimental evidence for developing miR-499a-based differentiation therapy for neuroblastoma.

Descriptors :   NEUROBLASTOMA

Distribution Statement : APPROVED FOR PUBLIC RELEASE