Accession Number : AD1003213


Title :   Cellular Plasticity and Heterogeneity of EGFR Mutant Lung Cancer


Descriptive Note : Technical Report,01 Sep 2014,31 Aug 2015


Corporate Author : Yale University New Haven United States


Personal Author(s) : Politi,Katerina


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1003213.pdf


Report Date : 01 Sep 2015


Pagination or Media Count : 12


Abstract : Phenotypic changes have been observed in EGFR mutant lung cancers that become resistant to targeted therapies. This grantaims to test the hypothesis that LUAD cells can transdifferentiate upon TKI treatment and to determine the cellular andmolecular mechanisms that regulate this process. We proposed to trace the cellular origin of EGFR mutant SCLC ingenetically engineered mouse models by using lineage tracing to test whether EGFR mutant LUAD cells can transdifferentiatealong the neuroendocrine lineage and to establish the molecular mechanisms that cause TKI resistance in EGFR mutantSCLCs. To date, we have made progress towards generating mouse models for the proposed lineage tracing experiments andhave begun genomic studies of pre- and post-treatment EGFR mutant tumors that transformed to SCLC following TKItreatment.


Descriptors :   LUNG CANCER


Distribution Statement : APPROVED FOR PUBLIC RELEASE