Accession Number : AD1002742


Title :   Development of a Guinea Pig Lung Deposition Model


Descriptive Note : Technical Report,10 Feb 2011,10 Jan 2012


Corporate Author : Applied Research Associates, Inc. Arlington United States


Personal Author(s) : Asgharian,Bahman


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1002742.pdf


Report Date : 01 Jan 2016


Pagination or Media Count : 23


Abstract : Guinea pigs have been used as a surrogate for humans in a number of inhalation toxicology studies by exposing the animals to airborne viruses, biological agents, and other chemicals. Findings from these studies can be extrapolated to humans based on a particular dose-metric of interest to determine potential health effects in humans. In the absence of exposure-dose data, mathematical models can be developed for the transport and deposition of inhaled particles in the lungs of guinea pigs to allow for predictions of lobar, regional, and local deposition of particles.


Descriptors :   toxicology , guinea pigs , inhalation


Distribution Statement : APPROVED FOR PUBLIC RELEASE