Accession Number : AD1002742

Title :   Development of a Guinea Pig Lung Deposition Model

Descriptive Note : Technical Report,10 Feb 2011,10 Jan 2012

Corporate Author : Applied Research Associates, Inc. Arlington United States

Personal Author(s) : Asgharian,Bahman

Full Text :

Report Date : 01 Jan 2016

Pagination or Media Count : 23

Abstract : Guinea pigs have been used as a surrogate for humans in a number of inhalation toxicology studies by exposing the animals to airborne viruses, biological agents, and other chemicals. Findings from these studies can be extrapolated to humans based on a particular dose-metric of interest to determine potential health effects in humans. In the absence of exposure-dose data, mathematical models can be developed for the transport and deposition of inhaled particles in the lungs of guinea pigs to allow for predictions of lobar, regional, and local deposition of particles.

Descriptors :   toxicology , guinea pigs , inhalation

Distribution Statement : APPROVED FOR PUBLIC RELEASE