Accession Number : AD1002603

Title :   Citrullinated Chemokines in Rheumatoid Arthritis

Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author : Regents of the University of Michigan Ann Arbor United States

Personal Author(s) : Fox,David A

Full Text :

Report Date : 01 Oct 2015

Pagination or Media Count : 54

Abstract : Citrullination, catalysed by peptidylarginine deiminase (PAD), is a post-translational modification of arginine to citrulline, which contributes to the pathogenesis of rheumatoid arthritis (RA). We show that citrullinated epithelial derived neutrophil-activating peptide 78/CXCL5 (cit-ENA-78/CXCL5) is significantly higher in RA synovial fluids(SFs) compared to osteoarthritis (OA) and other inflammatory rheumatic diseases (OD) SFs, and its concentration correlates with RA disease activity. Citrullinated chemokine concentrations were measured by enzyme linked immunosorbent assay (ELISA) in RA and normal (NL) sera and in RA, osteoarthritis (OA), and other inflammatory rheumatic disease (OD) synovial fluids (SFs). The correlation between the citrullinated chemokine levels and clinical data was analyzed. A strong correlation was found between the amounts of citENA-78/CXCL5 and Creactive protein or erythrocyte sedimentation rate (ESR) in RA SFs. These results indicate that citENA-78/CXCL5may have novel inflammatory properties in RA pathogenesis.

Descriptors :   arthritis , immunology , chemotaxis , health services , chemotactic factors , proteins , peptides

Distribution Statement : APPROVED FOR PUBLIC RELEASE