Accession Number : AD1002603


Title :   Citrullinated Chemokines in Rheumatoid Arthritis


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Regents of the University of Michigan Ann Arbor United States


Personal Author(s) : Fox,David A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1002603.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 54


Abstract : Citrullination, catalysed by peptidylarginine deiminase (PAD), is a post-translational modification of arginine to citrulline, which contributes to the pathogenesis of rheumatoid arthritis (RA). We show that citrullinated epithelial derived neutrophil-activating peptide 78/CXCL5 (cit-ENA-78/CXCL5) is significantly higher in RA synovial fluids(SFs) compared to osteoarthritis (OA) and other inflammatory rheumatic diseases (OD) SFs, and its concentration correlates with RA disease activity. Citrullinated chemokine concentrations were measured by enzyme linked immunosorbent assay (ELISA) in RA and normal (NL) sera and in RA, osteoarthritis (OA), and other inflammatory rheumatic disease (OD) synovial fluids (SFs). The correlation between the citrullinated chemokine levels and clinical data was analyzed. A strong correlation was found between the amounts of citENA-78/CXCL5 and Creactive protein or erythrocyte sedimentation rate (ESR) in RA SFs. These results indicate that citENA-78/CXCL5may have novel inflammatory properties in RA pathogenesis.


Descriptors :   arthritis , immunology , chemotaxis , health services , chemotactic factors , proteins , peptides


Distribution Statement : APPROVED FOR PUBLIC RELEASE