Accession Number : AD1002591


Title :   In Vivo Imaging of Cortical Inflammation and Subpial Pathology in Multiple Sclerosis by Combined PET and MRI


Descriptive Note : Technical Report,01 Sep 2014,31 Aug 2015


Corporate Author : Massachusetts General Hospital Boston United States


Personal Author(s) : Mainero,Caterina


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1002591.pdf


Report Date : 01 Sep 2015


Pagination or Media Count : 26


Abstract : Post-mortem studies in multiple sclerosis (MS) suggested that cortical demyelinating lesions, which are hardly detected in vivo on conventional magnetic resonance imaging (MRI) scans, are an important correlate of disability, and are driven by organized neuroinflammation with the activation of microglia. Activated microglia upregulate expression of the 18kDa translocator protein(TSPO), which can be imaged in vivo with [11C]PBR28, a second generation TSPO ligand. In this study, we combine ultra-high field 7 Tesla (T) MRI, which has demonstrated greater sensitivity to cortical lesions than conventional MRI, with [11C]PBR28 positron emission tomography (PET) imaging of activated microglia to assess whether more severe structural cortical pathology in MS is related to the presence of neuroinflammation. Our initial findings show that high-resolution [C]-PBR28 PET imaging is able to detect in vivo diffuse inflammation in different brain tissue compartments in MS, but more prominently in in cortex, cortical lesions, as well as deep gray matter. Additionally, the degree of inflammation in cortex, deep gray matter is associated with neurological disability, impaired information processing speed, a cognitive domain frequently affected in MS, and neurodegeneration.


Descriptors :   IMMUNE SYSTEM DISEASES , Cerebral cortex , lesions , cognition , NEURoDEGENERATIVE DISEASES , Magnetic resonance imaging , inflammation , brain , in vivo analysis


Distribution Statement : APPROVED FOR PUBLIC RELEASE