Accession Number : AD1002222


Title :   Improving Joint Function Using Photochemical Hydrogels for Articular Surface Repair


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2015


Corporate Author : Massachusetts General Hospital Boston United States


Personal Author(s) : Randolph,Mark A ; Gill,Thomas J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1002222.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 59


Abstract : The goal of our research is to introduce a novel means to regenerate the articular cartilage and restore normal function of the joint. A strategy that can generate durable hyaline articular cartilage, which will be predominantly type II collagen and, is capable of integrating with the surrounding cartilage matrix (without fissures) could improve the long-term outcome of joint surface repair. Several photochemically crosslinkable gels have been developed and tested in vitro and in vivo in miceincluding collagen, fibrin, PEG thiol-ene, and gelatin methacrylamide. All have shown satisfactory cell viability and some cartilage formation. A modification to using dynamic culture as a bioreactor has resulted in the formation of aggregates of chondrocytes called dynamic Sel-Regenrating cartialge (dSRC) that can be encapsulated in the gels. This has resulted in superior cartilage formation and has been tested in two swine in a pilot study. Long-term swine studies are underway.


Descriptors :   cartilage , Ethylene glycol , Crosslinking(Chemistry) , photochemistry , collagen , gels , Regeneration(Physiology) , Joints(Anatomy)


Distribution Statement : APPROVED FOR PUBLIC RELEASE