Accession Number : AD1002208

Title :   The Use of Inhibitors of Mechanosensitive Ion Channels as Local Inhibitors of Peripheral Pain

Descriptive Note : Technical Report,25 Feb 2011,24 Oct 2014

Corporate Author : Research Foundation of State University of Buffalo Buffalo United States

Personal Author(s) : Sachs,Frederick

Full Text :

Report Date : 01 Jan 2015

Pagination or Media Count : 133

Abstract : Mechanical pain is a major factor in the medical care of soldiers and veterans, whether in acute or chronic injury. Current analgesics, while effective, suffer from a potential for addiction and a variety of negative side effects. We have developed a new class of analgesics based on a peptide that is specific for inhibiting mechanosensitive ion channels. It is non toxic, acts peripherally, may be administered locally or systemically and may be non-addictive. This proposal is to explore the mechanism of action at the cell and molecular level and correlate nerve activation by mechanical stimulation in vitro with pain sensation in animals

Descriptors :   pain , analgesics , wounds and injuries , military personnel , inhibitors , health services

Distribution Statement : APPROVED FOR PUBLIC RELEASE