Accession Number : AD1001848

Title :   Magnetic Nanoparticles as Mechanical Actuators of Inner Ear Hair Cells

Descriptive Note : Technical Report,15 Jul 2012,30 Sep 2015

Corporate Author : University of California Los Angeles Los Angeles United States

Personal Author(s) : Bozovic,Dolores ; Cheon,Jinwoo

Full Text :

Report Date : 13 Jan 2016

Pagination or Media Count : 15

Abstract : The collaborative project was designed to develop the use of magnetic nanoparticles to manipulate auditory hair cells. Superparamagnetic particles were chemically modified so as to attach to stereocilia of the hair bundle. An electromagnet, positioned in the vicinity of a selected cell by a micromanipulator, was then used to apply a periodic force on the attached particle. We demonstrated that this system could be used to deflect hair bundles at frequencies up to 10 kHz. This technical breakthrough opens new possibilities for generalizing our nonlinear dynamics studies to higher frequencies auditory. The technique was applied to study higher-order phase-locking of oscillatory hair cells by an imposed drive. The results provided a potential model for how innate active bundle motility could be harnessed to detect higher frequency signals.

Descriptors :   MAGNETIC NANOPARTICLES , EAR , HAIR , Hearing

Subject Categories : Miscellaneous Materials
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE