Accession Number : AD1001437


Title :   Reinnervation of Paralyzed Muscle by Nerve-Muscle-Endplate Band Grafting


Descriptive Note : Technical Report,15 Sep 2014,14 Sep 2015


Corporate Author : Hackensack University Medical Center, Hackensack


Personal Author(s) : Mu,Liancai ; Sobotka,Stanislaw


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1001437.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 87


Abstract : The purpose of this research is to promote the efficacy of our recently developed new surgical technique called nerve-muscle-endplate band grafting (NMEG) for muscle reinnervation in a rat model. We modified the NMEG procedure by implanting the NMEG pedicle from a donor muscle into the native motor zone (NMZ) in the experimentally denervated muscle. Three months after surgery, functional recovery of the paralyzed muscles treated with the NMEG-NMZ technique was evaluated by muscle force measurement. The extent of nerve regeneration in the target muscle was assessed using immunohistochemical techniques. Our primary findings showed that NMEG-NMZ technique resulted in better functional recovery (82% of the control) as compared with our original NMEG procedure (67%). The NMEG-NMZ induced extensive nerve regeneration in the treated muscle. These results suggest that native motor zone in the skeletal muscle is anideal site for muscle reinnervation. NMEG-NMZ technique appears to have the potential for the treatment of muscle paralysis.


Descriptors :   MEDICAL RESEARCH , surgery , paralysis , muscles , donors(medicine)


Distribution Statement : APPROVED FOR PUBLIC RELEASE