Accession Number : AD1001437

Title :   Reinnervation of Paralyzed Muscle by Nerve-Muscle-Endplate Band Grafting

Descriptive Note : Technical Report,15 Sep 2014,14 Sep 2015

Corporate Author : Hackensack University Medical Center, Hackensack

Personal Author(s) : Mu,Liancai ; Sobotka,Stanislaw

Full Text :

Report Date : 01 Oct 2015

Pagination or Media Count : 87

Abstract : The purpose of this research is to promote the efficacy of our recently developed new surgical technique called nerve-muscle-endplate band grafting (NMEG) for muscle reinnervation in a rat model. We modified the NMEG procedure by implanting the NMEG pedicle from a donor muscle into the native motor zone (NMZ) in the experimentally denervated muscle. Three months after surgery, functional recovery of the paralyzed muscles treated with the NMEG-NMZ technique was evaluated by muscle force measurement. The extent of nerve regeneration in the target muscle was assessed using immunohistochemical techniques. Our primary findings showed that NMEG-NMZ technique resulted in better functional recovery (82% of the control) as compared with our original NMEG procedure (67%). The NMEG-NMZ induced extensive nerve regeneration in the treated muscle. These results suggest that native motor zone in the skeletal muscle is anideal site for muscle reinnervation. NMEG-NMZ technique appears to have the potential for the treatment of muscle paralysis.

Descriptors :   MEDICAL RESEARCH , surgery , paralysis , muscles , donors(medicine)

Distribution Statement : APPROVED FOR PUBLIC RELEASE