Accession Number : AD0729303


Title :   The Salivary Anti-A and Anti-B Isoantibody System in Group O Males.


Descriptive Note : Progress rept.,


Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY


Personal Author(s) : Bell,C Elliott , Jr ; Fortwengler,H Philip


Report Date : 20 Apr 1971


Pagination or Media Count : 20


Abstract : The incidence of anti-A and anti-B saliva agglutinins in group O males, the response of these agglutinins to parenteral immunization with A and B blood group substances, and the immunoglobulins responsible for this response were studied. In addition, the relationship of saliva agglutinin titers to titers of anti-A and anti-B antibodies in the corresponding sera was examined. Anti-A whole saliva agglutinins were detected in 98 percent and anti-B in 96 percent of 80 group O males. After subcutaneous injection of five group O males with A and B blood group substances, whole saliva anti-A agglutinins increased significantly in two individuals and anti-B in four, and parotid saliva anti-A agglutinins in one and anti-B in three. Both whole and parotid saliva agglutinating activity were demonstrated to be primarily due to secretory IgA, both pre- and postimmunization. IgG coating activity was also demonstrated in postimmunization whole saliva. In 80 group O males, whole saliva agglutinin titers of individuals with high-titer serum antibodies (saline agglutinins, neutralization-resistant antibodies, and hemolysins) were usually not insignificantly different from aliva titers of individuals with low-titer serum antibodies. (Author)


Descriptors :   *ANTIGENS , *BLOOD GROUPS , ANTIBODIES , SALIVA , IMMUNOLOGY , GAMMA GLOBULIN , ANTIGEN ANTIBODY REACTIONS , MALES


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE