Accession Number : AD0722663
Title : The Effect of Chronic Hypercapnia on Oxygen Affinity and 2, 3 Diphosphoglycerate as Related to Submarine Exposure
Descriptive Note : Interim rept.
Corporate Author : NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
Personal Author(s) : Messier, Arthur A ; Schaefer, Karl E
Report Date : 20 Jul 1970
Pagination or Media Count : 6
Abstract : The relationship between oxygen affinity and 2,3 diphosphoglycerate (2,3 DPG) in the red cell has been studied in chronic hypercapnia induced by prolonged exposure of guinea pigs to 15% CO2 in 21% O2. Red cell pH fell to a minimum after six hours of exposure and subsequently rose without reaching initial values after seven days of exposure. Both oxygen half-saturation pressure (P50) and the level of 2,3 DPG of the red cells followed the time course of the pH changes. However, both parameters required 24 hours to reach a minimum, following which they increased steadily and were not different from control values after seven days of exposure.
Descriptors : *CARBON DIOXIDE , *OXYGEN CONSUMPTION , *RESPIRATORY DISEASES , *SUBMARINE PERSONNEL , ERYTHROCYTES , PH FACTOR , STRESS(PHYSIOLOGY) , TOXICITY
Subject Categories : Stress Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE