Accession Number : AD0712666


Title :   EFFECTS OF HISTAMINE ON THE CEREBRAL VASCULATURE IN RHESUS MONKEYS.


Descriptive Note : Final rept. Jan-Mar 70,


Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX


Personal Author(s) : Watters,John W.


Report Date : JUL 1970


Pagination or Media Count : 14


Abstract : Cerebral angiography was performed on 20 rhesus monkeys, and the systemic blood pressure of these and 4 additional animals was monitored to determine the effects of injected doses of 150 and 300 micrograms/kg. of histamine. No significant difference was observed in the vessel diameters of the 150 micrograms/kg. group; however, the 300 micrograms/kg. group exhibited maximum constriction of the anterior cerebral artery 4 minutes after injection of histamine. Blood pressure fell rapidly until 1 to 4 minutes after the injections, at which time recovery progressed to 90% to 100% of preinjection levels in 30 minutes. Slight dilatation (103%-104%) of the anterior cerebral artery was in evidence 15 minutes after histamine administration. (Author)


Descriptors :   (*HISTAMINE, *CEREBROVASCULAR SYSTEM), BLOOD VESSELS, BLOOD PRESSURE, BRAIN, MONITORS, DOSAGE, BLOOD CIRCULATION, RADIOGRAPHY


Subject Categories : PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE