Accession Number : AD0712614


Title :   METABOLIC RESPONSE TO ACCELERATION IN MAN


Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX


Personal Author(s) : Lipman, Richard L ; Ulvedal, Frode ; Brown, William K ; Leverett, S D ; Lecocq, Frank R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/712614.pdf


Report Date : Mar 1970


Pagination or Media Count : 6


Abstract : The glucose analogue 2-deoxy-D-glucose (2-DG) was used as a means of producing intracellular hypoglycemia in eight normal male volunteer subjects during a control period, immediately following their initial exposure to acceleration (acute acceleration) and following their initial exposure to acceleration (acute acceleration) and following a fourth acceleration exposure (chronic acceleration). Plasma glucose, free fatty acids, serum immunoreactive growth hormone, plasma cortisol, and urinary epinephrine and norepinephrine were measured prior to and following the infusions of 2-DG. There were significant depressions in glucose, urinary epinephrine, cortisol and free fatty acids following acceleration that were not seen when compared to basal, unprovoked levels. Even with the modest acceleration stresses used in this study, discernible changes in gluco-regulatory hormone reserves were uncovered.


Descriptors :   *METABOLISM , ACCELERATION TOLERANCE , BIOCHEMISTRY , BLOOD CHEMISTRY , BLOOD PLASMA , CORTICOSTEROID AGENTS , EPINEPHRINE , FATTY ACIDS , FLIGHT , GLUCOSE , HORMONES , HYPOGLYCEMIA , SPACE FLIGHT , STRESS(PHYSIOLOGY)


Subject Categories : Biochemistry
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE