Accession Number : AD0476512


Title :   COCCIDIOIDIN SKIN TESTS AND SEROLOGIC RECTIONS IN IMMUNIZED AND INFECTED MONKEYS


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Lowe, Edwin P ; Sinski, James T ; Huppert, Milton ; Ray, John G , Jr


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/476512.pdf


Report Date : Dec 1965


Pagination or Media Count : 15


Abstract : The coccidioidin skin test and serologic reactions in immunized and nonimmunized monkeys are described. Experimental vaccines included killed intact cells and cell fraction antigens. Serologic tests included tube precipitin, two different agar gel immunodiffusion techniques, and two similar complement fixation (CF) tests. Skin and serologic activity was determined also in animals after aerosol infection. Both classes of reactions were greater in infected than in noninfected animals. However, the serologic response of monkeys to the disease differed in several aspects from that reported for man. Tube precipitin reaction was sporadic and where recorded tended to persist. Complement fixation reactions in infected monkeys were most nearly similar to those reported for man except that the monkey response generally was greater. Positive CF and agar gel immunodiffusion reactions were recorded in some animals early in the disease. Both types of argar gel immunodiffusion reactions paralleled the CF reactions, and they may all be tests for the same antibody. The value of these tests in immunologic studies in vivo with Coccidioides immitis is discussed.


Descriptors :   *VACCINES , *ANTIGEN ANTIBODY REACTIONS , *COCCIDIOIDES , IMMUNOLOGY , IMMUNITY , IN VIVO ANALYSIS , SERODIAGNOSIS , BIOASSAY , MONKEYS , DIAGNOSTIC AGENTS , HISTOLOGICAL TECHNIQUES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE