Accession Number : AD0474986


Title :   NATURAL DRUG RESISTANCE OF HETEROGENEOUS SINGLE CELL TRANSPLANTS


Descriptive Note : Final rept. 17 Sep 1964-16 Sep 1965


Corporate Author : SASAKI FOUNDATION MEDICAL INSTITUTION TOKYO (JAPAN)


Personal Author(s) : Yoshida, Tomizo


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/474986.pdf


Report Date : 29 Sep 1965


Pagination or Media Count : 25


Abstract : Population analysis of a cancer clone derived from a single cancer cell was made, using a clonal transplant-strain of the rat ascites hepatoma, CL- 1-AH-66F. The natural resistance to nitrogen mustard N-oxide and the chromosomal constitution were studied, after establishing subclonal tumors from the original clone CL-1-AH-66F. The results indicated the following facts: (1) The cancer clone is not a uniform but a complex population of cells with different degrees of drug resistance. (2) The degree of drug resistance of the original clone and its subclones varies naturally within a certain range during serial passages of them in compatible hosts. (3) No specific correlation was found between the degree of drug resistance and chromosomal feature of the subclones. (4) It was suggested that the variation in drug resistance of cancer clone is not always associated to the genetic heterogeneity of cells in the cancer clone.


Descriptors :   *CANCER , TISSUE CULTURE CELLS , CHROMOSOMES , DRUGS , GENETICS , TRANSPLANTATION , TOLERANCES(PHYSIOLOGY) , CHEMOTHERAPY , NITROGEN MUSTARDS , GROWTH(PHYSIOLOGY) , CYTOLOGY


Subject Categories : Biochemistry
      Anatomy and Physiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE