Accession Number : AD0473836


Title :   RECOMBINATION AND TRANSMISSION STUDIES WITH INFLUENZA VIRUS


Descriptive Note : Annual rept. 1 Nov 1964-31 Oct 1965


Corporate Author : CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK


Personal Author(s) : Kilbourne, Edwin D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/473836.pdf


Report Date : 31 Oct 1965


Pagination or Media Count : 25


Abstract : This report discusses the production of a variety of antigenic hybrids - influenza virus recombinants that can be shown to possess antigens typical of both parents. Such hybrids may be produced by matings among any of the human influenza A subtypes and by matings of swine influenza virus and an A strain. It has also been shown that the proportion of parental antigens of such recombinants may vary and that mating of recombinant virus with the parent that contributed to minor antigenic component may increase the recognizable amount of such component in subsequent progeny. Antigenically hybrid viruses are not heterozygote and they are stable and they can be used to infect mice, in which they produce at least partial immunity to both parental viruses. The implications for immunization of man are clear. It also appears possible that the reshuffling of demonstrable antigens in viruses by recombination may lead to the production of antigenically novel viruses - particularly if it is assumed that all antigens in differing amounts are present in all human influenza A strains. Evidence of this is provided by the induction of heterotypic immunity in mice by a single infection.


Descriptors :   *GENETICS , *INFLUENZA VIRUS , AEROSOLS , VIABILITY , LUNG , ANTIBODIES , CORTICOSTEROID AGENTS , EMBRYONATED EGG TECHNIQUE , TISSUE CULTURE , ANTIGENS , PATHOLOGY , MICE , IMMUNITY


Subject Categories : Biology
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE