Accession Number : AD0470479


Title :   STAPHYLOCOCCAL EXTEROTOXEMIA: PATHOLOGIC LESIONS IN RHESUS MONKEYS EXPOSED Y AEROSOL


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Soto, Jr , Peter J ; Roessler, William G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/470479.pdf


Report Date : Sep 1965


Pagination or Media Count : 18


Abstract : Thirty rhesus monkeys were given purified staphylococcal enterotoxin B aerogenically. A method for calculating the dosage is referenced. Twenty-two animals responded with emesis and/or diarrhea within 5 hours after exposure, 9 died spontaneously, and 21 were sacrificed sequentially up to 7 days after exposure. The only pathologic lesions attributable to the challenge were severe pulmonary edema (with resolving fibrinous exudate in one animal sacrificed at 7 days), edematous enlargement of the tracheobronchial lymph nodes, and vacuolar nephropathy, presumably of hypokalemic origin, in one instance. Alveolar capillary block from pulmonary edema seemed the most important cause of death in nine animals. Eight challenged and two control animals remained sympton-free and showed none of the above lesions postmortem. Other possible mechanisms of death are discussed. The absence of significant lesions in the gastrointestinal tract strongly suggests that enterotoxemia occurred, and that emesis and diarrhea may have been caused by toxic injury to appropriate areas in the medulla and pons.


Descriptors :   *STAPHYLOCOCCUS , TOXICITY , PATHOLOGY , INFECTIOUS DISEASES , MONKEYS , BIOASSAY , SURVIVAL(PERSONNEL) , TOXINS AND ANTITOXINS


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE