Accession Number : AD0470444


Title :   EFFECT OF WHOLE SALIVA ON PERFORMANCE OF 0.1% STANNOUS FLUORIDE MOUTHWASH.


Descriptive Note : Final rept. Nov 64-Feb 65,


Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX


Personal Author(s) : Shannon,Ira L


Report Date : Jul 1965


Pagination or Media Count : 5


Abstract : The use of 25-ml, portions of a flavored 0.1% stannous fluoride mouthwash produced a mean whole while saliva flow rate of 1.95 ml./min. when tested over two successive 1-minute periods. The mean of 2.16 ml./min. for the second 1-minute period was significantly higher than that of 1.74 ml./min. for the initial interval. A control preparation containing 0.1% stannous fluoride provided enamel surfaces with 45.5% (S.E. = 2.34) protection against acid decalcification. The dilution of 25.0 ml. of this mouthwash with 2.0, 5.0, and 10.0 ml. of water did not significantly reduce protective efficacy. The addition of identical amounts of pooled human whole saliva decreased protective performance to 34.5% (S.E. = 2.27), 26.9% (S.E. = 2.06), and 15.3% (S.E. = 1.72), respectively. Each of these decreases in protective capacity was highly significant. The decrease in effectiveness of the mouthwash in the presence of whole saliva in no way contraindicates the use of this preparation. The average flow of saliva was found to dilute the mouthwash by approximately 8% and, in the laboratory, this dilution provided a protective effectiveness of about 35% against acid decalcification. (Author)


Descriptors :   *TEETH , FLUORIDES , GERMICIDES , FLUID FLOW , SALIVA , BIOCHEMISTRY , DENTISTRY , MEDICAL RESEARCH , ACIDS , DEGRADATION


Distribution Statement : APPROVED FOR PUBLIC RELEASE