Accession Number : AD0469389


Title :   PASTEURELLA PESTIS: ROLE OF PESTICIN I AND IRON IN EXPERIMENTAL PLAGUE


Descriptive Note : Technical manuscript


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Brubaker, Robert R ; Beesley, Earl D ; Surgalla, Michael J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/469389.pdf


Report Date : Jul 1965


Pagination or Media Count : 11


Abstract : Loss of the genetic determinant for pesticin I in Pasteurella pestis results in concomitant loss of the plague coagulase and fibrinolytic factor. The LD50 for mice of an isolate lacking only these activities is increased by factors of about 10 to the minus 1 power, 10 to the 4th power, and 10 to the 7th power cells when administered by the intravenous, intraperitoneal, and subcutaneous routes, respectively. Virulence of this isolate can be enhanced in mice treated with 40 micrograms of ferrous iron. This response resembles that of Pasteurella pseudotuberculosis, a closely related species that normally lacks pesticin I.


Descriptors :   *BIOCHEMISTRY , *YERSINIA PESTIS , ANALYSIS OF VARIANCE , METABOLISM , MUTATIONS , VIABILITY , GENETICS , LETHAL DOSAGE , VEINS , ABDOMEN , INJECTIONS(MEDICINE) , SUBCUTANEOUS TISSUE , BIOLOGICAL PRODUCTS , IRON ORGANIC COMPOUNDS , FIBRINOLYSIS , YERSINIA PSEUDOTUBERCULOSIS


Subject Categories : Microbiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE