Accession Number : AD0468161


Title :   PATHOGENESIS OF THE LETHAL EFFECT OF ANTHRAX TOXIN IN THE RAT: I. PHYSIOLOGIC AND PHARMACOLOGIC STUDIES


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Beall, Francis A ; Dalldorf, Frederic G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/468161.pdf


Report Date : Jul 1965


Pagination or Media Count : 19


Abstract : The pathogenesis and nature of the pulmonary edema caused by lethal doses of anthrax toxin in Fischer 344 rats were investigated. It was shown that massive pulmonary edema developed only after a lag period during which signs of illnes were absent. The protein content and electrophoretic analyses of exudates collected from rats killed by toxin indicated that plasma had escaped from the pulmonary circulation. Following injection of sublethal doses of toxin, a delayed but prolonged vascular leakage in pulmonary, peritoneal, and subcutaneous vascular beds was also demonstrated. Pulmonary edema was not prevented nor was survival time increased by treating rats with drugs inhibiting histamine or serotonin or with drugs blocking the autonomic nervous system at several sites.


Descriptors :   *BACILLUS ANTHRACIS , TOXINS AND ANTITOXINS , LETHAL DOSAGE , LUNG , PATHOLOGY , EDEMA , PHARMACOLOGY , ANTIHISTAMINICS , SEROTONIN , SYMPATHOLYTIC AGENTS , ATROPINE , SURVIVAL(PERSONNEL) , THERAPY , RATS


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE