Accession Number : AD0467125


Title :   BASIC BIOLOGY AND TROPISTIC BEHAVIOR OF SCHISTOSOMA MANSONI CERCARIAE RELATING TO CERCARICIDAL AGENTS.


Descriptive Note : Annual rept., Jul 64-Jun 65,


Corporate Author : MINAS GERAIS UNIV BELO HORIZONTE (BRAZIL) INSTITUTO DE BIOLOGIA


Personal Author(s) : Pellegrino,Jose


Report Date : 30 Jun 1965


Pagination or Media Count : 9


Abstract : Several compounds were studied for repellent activity. Most promising is the oil from seeds of Pterdon pubescens which gave lasting protection against infection, even when diluted to 5% soln. in DMSO or ether. Repellents DEET and Entoral were not effective. Intradermal test for diagnosis was improved and purified materials developed. Techniques were developed to permit large scale culture of snail hosts and cercariae in the laboratory. A number of proposed compounds were tested after development of routine procedures. No correlation between in vitro and in vivo activities. Methods were developed for infection f hamster thru cheek pouch for screening. Studies continue on these problems and on tropistic behavior of cercariae. (Author)


Descriptors :   *SCHISTOSOMA , INFECTIOUS DISEASES , CHEMOTHERAPY , DIAGNOSIS(MEDICINE) , DRUGS , VEGETABLE OILS


Distribution Statement : APPROVED FOR PUBLIC RELEASE