Accession Number : AD0466772


Title :   CHANGES IN TOTAL BODY SODIUM, AND BODY WATER DURING ACUTE CHOLERA AND DURING MAINTENANCE THERAPY,


Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA


Personal Author(s) : Vaughan, B E ; Martin, R L ; Wallace, C K ; Blackwell, Q ; Reyes, A L


Report Date : 29 Mar 1965


Pagination or Media Count : 22


Abstract : Tracer studies of fluid compartment changes were made possible during the 1961 cholera outbreak in Manila, Philippine Islands. TBW, Nae, ECF and intracellular fluid shifts were measured during rehydration therapy and durring controlled periods of diarrheal dehydration. When fecal, urine and estimated insensible losses are replaced by equivalent volumes of isotonic NaCL at a plasma specific gravity of 1.024, some degree of sodium loading occurs. For otherwise normal patients, this would lie within reasonable range of renal compensation. At high fecal outputs, the tracer sodium initially excreted into the gut appears not to be reabsorbed, and it is delayed several hours in appearing in stool. Cholera dehydration causes marked depletion of extracellular water with comparatively small losses from intracellular water. (Author)


Descriptors :   *SODIUM , CHOLERA , BODY FLUIDS , METABOLISM , DEHYDRATION , BLOOD PLASMA , BLOOD VOLUME , WATER , STABILIZATION , BIOASSAY , EXCRETION , ELECTROLYTES(PHYSIOLOGY) , GASTROINTESTINAL SYSTEM , LABELED SUBSTANCES , RADIOACTIVE ISOTOPES , BICARBONATES , POTASSIUM , DIARRHEA , BIOLOGICAL ABSORPTION


Distribution Statement : APPROVED FOR PUBLIC RELEASE