Accession Number : AD0464951


Title :   Biological Safety Evaluation of a Commercial Vaccine Production Laboratory


Descriptive Note : Technical rept.


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Barbeito, Manuel S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/464951.pdf


Report Date : May 1965


Pagination or Media Count : 81


Abstract : Operation of buildings and equipment for work with pathogenic microorganisms often involves inherent hazards unknown to personnel responsible for design, construction, budgeting, or research. To a significant extent the facilities and equipment of a laboratory building will aid or deter efforts of operating personnel in maintaining good environmental control and in preventing laboratory infections. The tests reported here were designed to evaluate the microbiological hazards associated with equipment, general building design, construction, operational features, effluent treatment system, and routine research operations in a newly constructed vaccine production facility. The testing procedures and equipment used are described or referenced and the results are tabulated to show the method used to assess the microbiological hazards. The risks to personnel are characterized, and methods are recommended to improve operation of the building as designed, to modify equipment, and to eliminate hazards.


Descriptors :   *BIOLOGICAL LABORATORIES , HAZARDS , VENTILATION , BENDING , SAMPLING , INFECTIOUS DISEASES , COUNTERMEASURES , LABORATORY EQUIPMENT , SYSTEM SAFETY , MICROBIOLOGY , VACCINES , LABORATORY ANIMALS , SANITARY ENGINEERING , CONTROLLED ATMOSPHERES , BACTERIAL AEROSOLS


Subject Categories : Safety Engineering


Distribution Statement : APPROVED FOR PUBLIC RELEASE