Accession Number : AD0464196


Title :   EFFECT OF ENZYMATIC FUNCTIONAL GROUP INHIBITORS ON PROTEOLYTIC ENZYMES OF CROTALUS ATROX VENOM


Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY


Personal Author(s) : Brown, John H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/464196.pdf


Report Date : 05 Apr 1965


Pagination or Media Count : 46


Abstract : Crotalus atrox venom proteases are inhibited by several functional group specific inhibitors. Heavy metal ions inhibit, whereas calcium and other divalent alkaline earths have a general activating effect on these proteases. The type and number of proteases in crude venom can be discerned by combined use of these reagents and four different substrates. Two of these substrates, N- benzoyl-DL-arginine-p-nitroanilide and congocoll have recently been introduced as substrates for trypsin, but have not as yet been used to assay proteolytic enzyme activity of snake venoms.


Descriptors :   *VENOMS , PEPTIDE HYDROLASES , MAGNESIUM , CALCIUM , BIOCHEMISTRY , ENZYMES , BIBLIOGRAPHIES , COPPER , MERCURY , ZINC , CADMIUM , NICKEL , INHIBITION , PH FACTOR , COBALT , MANGANESE , IONS , METALS


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE