Accession Number : AD0456333


Title :   COCCIDIOIDIN SENSITIVITY IN CONTROL, IMMUNIZED, AND INFECTED GUINEA PIGS


Descriptive Note : Technical Manuscript


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Sinski, James T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/456333.pdf


Report Date : Jan 1965


Pagination or Media Count : 18


Abstract : Delayed hypersensitivity to undiluted coccidioidin developed in guinea pigs immunized with dead C. immitis arthrospores and guinea pigs infected with an aerosol of C. immitis arthrospores at weeks 1 and 2. Delayed hypersensitivity in control animals sensitized by repeated intradermal testing developed at weeks 3 and 4. The delayed hypersensitivity responses were characterized grossly by indurations larger than 25 mm2 and could be seen at 6 and 24 hours after testing. Retesting reduced the size of the 24-hour indurations compared with virginal reactions. The retest delayed reactions in infected animals had indurations at 24 and 48 hours that were larger than those in the other groups. In those animals that were skin-test-positive but not challenged, no tube precipitins, agar gel precipitins, complement fixing antibodies, anaphylaxis, or immediate hypersensitivity was detected. Because of the lack of precipitins and the inability to produce anaphylaxis, the early phase of the hypersensitivity seen at 6 hours was not considered an Arthus reaction.


Descriptors :   *TISSUE EXTRACTS , *COCCIDIOIDES , AEROSOLS , TEST METHODS , SENSITIVITY , FUNGI , IMMUNITY , SKIN(ANATOMY) , VACCINES , ANTIGEN ANTIBODY REACTIONS , GUINEA PIGS


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE