Accession Number : AD0456168


Title :   IMMUNOGENIC POTENCY OF PASTEURELLA TULARENSIS CELL WALLS


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Guss, Maruice L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/456168.pdf


Report Date : Jan 1965


Pagination or Media Count : 12


Abstract : Purified cell walls of sonically disrupted viable Pasteurella tularensis strains SCHU S5 and 38A were evaluated for immunogenic properties in the monkey (Macaca mulatta). Subcutaneous vaccination with 12 mg of the larger cell-wall particles (sedimenting at 30,000 x g), either in one site or equally divided among 6 sites, evoked no febrile response, caused few skin lesions, and stimulated a rapid agglutinin response. Protection afforded animals vaccinated with the wall fraction of strain SCHU S5 indicated promise of definition of the sites of the antigens in the cell that are involved in evoking immunity and potential for the preparation of an effective nonviable vaccine.


Descriptors :   *VIABILITY , *VACCINES , *FRANCISCELLA TULARENSIS , PURIFICATION , PATHOLOGY , IMMUNOLOGY , ANTIGENS , CELL WALL , MONKEYS , IMMUNOGENS , TISSUE EXTRACTS , AGGLUTININS


Subject Categories : Microbiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE