Accession Number : AD0455003


Title :   THE EFFECTS OF X-IRRADIATION ON THE ANTIGENIC CHARACTER OF ANCISTRODON PISCIVORUS (COTTONMOUTH MOCCASIN) VENOM,


Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY


Personal Author(s) : Flowers, Herschel H


Report Date : 10 Jul 1964


Pagination or Media Count : 9


Abstract : X-irradiated cottonmouth moccasin venom (Ancistrodon piscivorus) which exhibited reduced local and lethal properties was studied to determine alterations in its antigenic character. Antibody titers of rabbits immunized with X-irradiated venom were compared to those of rabbits immunized with untreated venom. Studies indicated the antisera produced by injections of X-irradiated venom contained 80% of the neutralization titer of antisera produced by untreated venom, and effectively neutralized both the local and lethal effects of untreated venom. Animals immunized with X-irradiated venom suffered no mortality and much less local tissue damage than the group immunized with untreated venom. (Author)


Descriptors :   *ANTIGENS , *VENOMS , ANTIGENS , ANTIBODIES , ANTIBODIES , RADIATION EFFECTS , RADIATION EFFECTS , REPTILES , BLOOD ANALYSIS , HEMORRHAGE , NECROSIS , TOXICITY , ENZYMES , RABBITS , GLOBULINS , LETHAL DOSAGE , SURVIVAL(PERSONNEL)


Distribution Statement : APPROVED FOR PUBLIC RELEASE