Accession Number : AD0454629


Title :   STUDIES ON THE RADIOSENSITIVE PHASE OF THE PRIMARY ANTIBODY RESPONSE. I. TRANSFER OF ANTIBODY FORMATION TO IRRADIATED ANIMALS BY SENSITIZED MACROPHAGES AND NORMAL LYMPHOID CELLS FROM NONIRRADIATED RABBITS,


Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA


Personal Author(s) : Pribnow, J. F. ; Silverman, M. S.


Report Date : 07 DEC 1964


Pagination or Media Count : 17


Abstract : Irradiated rabbits receiving both rabbit peritoneal monocytes incubated with bovine gamma globulin and lymph node cells from the monocyte donors were able to produce antibody. Irradiated rabbits injected with sensitized monocytes alone failed to show an antibody response. Normal recipients of these cells exhibited a typical primary antibody response, although titers were lower than in controls receiving antigen alone. Normal and irradiated rabbits receiving lymph node cells incubated with antigen failed to produce antibody, as did irradiated rabbits receiving simultaneous injection of antigen and lymph node cells. The implications of these findings in relation to the radiosensitive phase of the immune response, and to current concepts of the mechanisms of antibody synthesis are discussed. (Author)


Descriptors :   , (*ANTIGENS, ANTIBODIES, RADIATION EFFECTS), (*IMMUNOLOGY, RADIOBIOLOGY), LABORATORY ANIMALS, RABBITS, STIMULATION(PHYSIOLOGY), X RAYS, SENSITIVITY, DETERMINATION, MEASUREMENT, LYMPHOCYTES.


Distribution Statement : APPROVED FOR PUBLIC RELEASE