Accession Number : AD0451612


Title :   THE CO2-BINDING CAPACITY OF RAT BRAIN TISSUE IN VIVO,


Corporate Author : LUND UNIV (SWEDEN)


Personal Author(s) : PONTEN,U


Report Date : 23 Jan 1964


Pagination or Media Count : 4


Abstract : There has been no systematic determination of the carbon dioxide binding capacity of brain tissue in vivo and the scattered values which exist have been based on tissue material subjected to post mortem changes. It has been shown that accurate analysis of the acid-base metabolism of the brain requires that the tissue is frozen in situ. Carbon dioxide dissociation curves on brain tissue homogenates, on the other hand, do not truly reflect the in vivo buffer capacity of the tissue, since this capacity may involve active transport mechanisms as well as metabolically induced changes of the tissue buffer systems. The present study, which is part of a systematic investigation of the acid-base metabolism of brain tissue, describes the carbon dioxide binding capacity of rat brain tissue exposed to arterial carbon dioxide tensions of 12-107 mm Hg. (Author)


Descriptors :   *CARBON DIOXIDE , BRAIN , ACID BASE EQUILIBRIUM , TISSUES(BIOLOGY) , METABOLISM , RATS , BUFFERS , CORRELATION TECHNIQUES , RESPIRATION , BIOCHEMISTRY


Distribution Statement : APPROVED FOR PUBLIC RELEASE