Accession Number : AD0450389


Title :   EXPOSURE OF GUINEA PIGS TO X-IRRADIATION AND P. TULARENSIS OF REDUCED VIRULENCE


Descriptive Note : Technical manuscript


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Nutter, John E ; Eigelsbach, Henery T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/450389.pdf


Report Date : Sep 1964


Pagination or Media Count : 12


Abstract : Studies were conducted to determine and evaluate potential changes in susceptibility, resistance to infection, serology, and subsequent immunity of the guinea pig irradiated before or after respiratory exposure to normally innocuous doses of P. tularensis strain 38A (avirulent) or LVS (live vaccine strain). A 1000-KVP X-ray unit was used for irradiation and it was established that 140 R constituted the maximal sublethal dose for the 325- to 375-g, male, Hartley strain, guinea pig. Although all control animals administered either 140 R of irradiation or P. tularensis via the respiratory route survived, fatalities occurred in animals receiving the combination; and greatest mortality was observed in guinea pigs irradiated prior to respiratory exposure. Exposure of irradiated animals to 38A or LVS did not modify the classical leucopenia normally observed following irradiation; and nonirradiated animals exposed to LVS or 38A exhibited no marked change in blood picture.


Descriptors :   *RADIATION EFFECTS , *FRANCISCELLA TULARENSIS , RESPIRATORY SYSTEM , PATHOLOGY , SURVIVAL(PERSONNEL) , IMMUNITY , LETHAL DOSAGE , BLOOD , MICROORGANISMS , GUINEA PIGS , BLOOD CELLS , SUBLETHAL DOSAGE


Subject Categories : Microbiology
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE