Accession Number : AD0450109


Title :   ANTIGENICITY OF IRRADIATED PASTEURELLA TULARENSIS VACCINES IN MICE


Descriptive Note : Technical Manuscript


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Gordon, Milton ; Donaldson, David M ; Green, Leonard


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/450109.pdf


Report Date : Aug 1964


Pagination or Media Count : 10


Abstract : Viable attenuated tularemia vaccines have been shown to be effective in immunizing mice and other animals against challenge with highly virulent Pasteurella tularensis. Preparations made nonviable by the action of heat or chemicals, however, induce little or no resistance to challenge with even small numbers of virulent organisms. In these studies, vaccines rendered nonviable by the action of ionizing radiation produced levels of immunity such that 20 to 30% of immunized mice survived intraperitoneal challenge with moderate doses of the highly virulent SCHU S4 strain of P. tularensis. Both x- and electron beam- irradiation were effective in preparing the vaccine, which contained from 1.4 x 10 to the 8th power to 4.0 x 10 to the 9th power nonviable organisms per milliliter.


Descriptors :   *RADIATION EFFECTS , *FRANCISCELLA TULARENSIS , X RAYS , ELECTRON BEAMS , VIABILITY , MICE , IMMUNITY , RADIATION DOSAGE , VACCINES , RADIATION TOLERANCE


Subject Categories : Radiobiology
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE