Accession Number : AD0449730


Title :   EFFECT OF CORTISONE ON PROTECTION AGAINST RELATED ARBOVIRUSES IN VACCINATED MICE


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Allen, William P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/449730.pdf


Report Date : Aug 1964


Pagination or Media Count : 11


Abstract : Protection of mice vaccinated with Group A arboviruses against challenges with heterotypic viruses was investigated to determine whether or not resistance is fully manifested prior to challenge, or if such resistance develops as a result of the challenge stimulus. Cortisone acetate was administered intramuscularly in four daily doses of five mg each commencing the day before inoculation of the challenge virus to suppress the immune response to the challenge stimulus. This treatment inhibited protection against Venezuelan equine encephalitis virus (VEE) in mice previously vaccinated with Sindbis virus. Protection against Semliki Forest virus (SF) was partially inhibited by cortisone in mice vaccinated with VEE or Sindbis viruses. Homologous protection in immune mice was essentially unaltered by cortisone treatment. The data suggest that for certain cross-protection systems resistance to heterotypic viruses is manifested in the vaccinated animal as a result of the challenge stimulus.


Descriptors :   *GROUP A ARBOVIRUSES , *ADRENAL CORTEX HORMONES , STIMULATION(PHYSIOLOGY) , MICE , IMMUNITY , VACCINES , CORTICOSTEROID AGENTS , SEMLIKI VIRUS , VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE