Accession Number : AD0449590


Title :   PROLIFERATION OF HEMOPOIETIC COLONY-FORMING CELLS TRANSPLANTED INTO IRRADIATED MICE,


Corporate Author : TORONTO UNIV (ONTARIO)


Personal Author(s) : McCulloch, E A ; Till, J E


Report Date : 11 Nov 1963


Pagination or Media Count : 15


Abstract : The kinetics of proliferation of spleen colonyforming cells derived from transplanted marrow cells have been studied by means of two different methods. The results of thest experiments indicate that transplanted colony-forming cells do not proliferate in heavily irradiated receipients during the first day after transplantation, but that after this initial lag phase they increase in number in an exponential fashion for at least the next 7 days, with a doubling time of 20 to 25 hours. A transient increase in the Do of the survival curve for transplanted colony-forming cells derived from marrow was observed during the posttransplantation lag phase. This increase was maximal approximately 1 day after transplantation. (Author)


Descriptors :   *HEMATOPOIETIC SYSTEM , RADIATION EFFECTS , CELLS(BIOLOGY) , REGENERATION(ENGINEERING) , RADIATION DOSAGE , MICE , TRANSPLANTATION , GROWTH(PHYSIOLOGY) , SURVIVAL(PERSONNEL) , BONE MARROW


Distribution Statement : APPROVED FOR PUBLIC RELEASE