Accession Number : AD0449588


Title :   INOSITOL AND THE PROTECTION CELLS. I. THE RELEASE OF NUCLEIC ACIDS AND VIRUSES FROM BACTERIAL AND MAMMALIAN CELLS,


Corporate Author : SASKATCHEWAN UNIV SASKATOON


Personal Author(s) : Webb, S J ; Cook, C A M ; Bather, R


Report Date : 21 May 1963


Pagination or Media Count : 8


Abstract : The effect has been studied of inositol on the release of nucleic acids from bacterial cells dried at different relative humidities (R.H.) and from animal cells suspended in inositol solutions. Drying at 60% R.H. or above, or treatment with inositol brings about the release of RNA and active virus, but otherwise does not affect the cell. The release of this nucleic acid appears to enable tge cell to withstand adverse drying conditions and it is suggested that cell death results from a malfunction in the activity of specific enzymes concerned in RNA syntgesis. Some applications of the findings with respect to the problems of virus spread and tumor formation are discussed. (Author)


Descriptors :   *BACTERIAL EXTRACTS , SUGAR ALCOHOLS , VIRUSES , NUCLEIC ACIDS , CELLS(BIOLOGY) , DEHYDRATION , ENZYMES


Distribution Statement : APPROVED FOR PUBLIC RELEASE