Accession Number : AD0448700


Title :   ACUTE TOXICITY OF TETRAHYDROCANNABINOL TO MICE IN ALTERED ENVIRONMENTS


Descriptive Note : Technical rept.


Corporate Author : CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD


Personal Author(s) : Frochlich, Harry L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/448700.pdf


Report Date : Sep 1964


Pagination or Media Count : 22


Abstract : A dose range study and an acute intraperitoneal toxicity study were performed with tetrahydrocannabinol. The purpose was to determine whether any differences in physiological activity or acute intraperitoneal toxicity (LD50) could be observed in mice housed at room temperatures of 70 degrees and 40 degrees F. Mice receiving tetrahydrocannabinol at a room temperature of 40 F exhibited the same physiological effects as mice receiving tetrahydrocannabinol at a room temperature of 70 degrees F. The acute intraperitoneal LD50 of tetrahydrocannabinol in mice at 70 F was 125=37 mg/kg. The acute intraperitoneal LD50 of tetrahydrocannabinol in mice at 40 F was 14=2mg/kg. Tetrahydrocannabinol is nine times more toxic in mice subjected to the added stress of cold.


Descriptors :   *DRUGS , *CANNABINOLS , TEMPERATURE , TOXICITY , BIOCHEMISTRY , PHYSIOLOGICAL EFFECTS , ENVIRONMENTAL TESTS , PHYSIOLOGY , MICE , SURVIVAL(PERSONNEL) , HYPOTHERMIA , LETHAL DOSAGE , PHARMACOLOGY , ABDOMEN


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE